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11 of May, 2022
3 Reasons For Inconclusive Results Of An NIPT Test

During pregnancy, opting for a non-invasive prenatal test has become the norm. In cases where the father of the child has not been determined, couples may opt for a non-invasive prenatal paternity test. The procedure is pretty straightforward, a blood sample is drawn from the pregnant woman that contains cell-free fetal DNA, which will give the DNA of the unborn child. The DNA sample of the potential father is collected through a buccal swab, and the two samples are compared to determine paternity. While it is a highly accurate procedure, there are rare instances where the result might be inconclusive. Here are 3 factors that can lead to such a result. 

Reasons behind an inconclusive prenatal paternity test.

Low Fetal Fraction

Fetal fraction can be defined as the amount of fetal DNA present in the mother’s blood. It has to be at least above 4 percent to give a conclusive result. If the concentration of fetal DNA is below this, then the test might prove to be inconclusive. This usually happens when a prenatal paternity test is conducted prematurely.


Chromosomal Abnormalities

While it is not certain by any means, getting no result during a NIPT test might point toward an increased chance of chromosomal abnormalities. Of course, this can be dispelled with subsequent retests. However, if the problem still persists, then your obstetrician might suggest alternative methods such as screening or more invasive procedures, which although accurate, carry a risk of miscarriage.


Miscellaneous Factors

Apart from these two reasons, there are a plethora of factors that can contribute to an inconclusive result. One such factor is high maternal weight. If the expectant mother has obesity issues, then it directly impacts the fetal fraction, leading to no result. Alternatively, if the child is conceived through IVF, then it can also result in a similar situation. Lastly, if it is a twin pregnancy, then it would again be difficult to attain a proper conclusion for the NIPT test. 


Thus, if you received no result during your non-invasive prenatal paternity test, then it might be best to check if any of these 3 factors might be in play. 


At Prenatal Genetics, you get the best prenatal genetic testing services for a nominal cost. Run by research scientists who are experts in human DNA diagnostics, we also offer express shipping services to reduce waiting time. Contact us today to learn more about everything that we can do for you.

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